The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens.
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چکیده
منابع مشابه
The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens
Cytotoxic cells were generated by immunizing one strain of mouse with cells from an allogeneic strain which carries the same H-2 region. The effector cells assayed in a 4 h 51Cr release assay were shown to be T cells and indistinguishable, except in specificity, from cytotoxic T cells directed at H-2 alloantigens. Although the genetic differences between responder and stimulator cells responsib...
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ISTOCOMPATIBILITY antigens are a group of cell H membrane alloantigens that can trigger T-lymphocyte proliferative and/or cytolytic activity in vitro and may initiate graft rejection or graft-versus-host disease (GVHD) in vivo. AB0 and related antigens, whose presence on vascular endothelial cells may provoke antibody-mediated graft rejection, are excluded from this group because they do not in...
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Clinical studies indicated an enhanced antileukemic effect of allogeneic bone marrow transplantation (BMT), as compared with autologous BMT. After allogeneic HLA-identical BMT, donor-derived cytotoxic T lymphocytes (CTLs) directed at minor histocompatibility (mH) antigens on the recipients, tissues can be shown. To evaluate the antileukemic reactivity of mH antigen-specific CTLs, we analyzed th...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1975
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.142.6.1349